News

News

Monday
October, 3

A berry from Brazil helps out — ScienceDaily

[ad_1]

Castalagin, a polyphenol from the Amazonian fruit camu-camu, increases the efficacy of immunotherapy in mice by modifying their microbiome, Canadian researchers find.

Canadian researchers have discovered that the Brazilian camu-camu berry, already recognized for its protective effects against obesity and diabetes, can also help to treat cancers.

In a study published in Cancer Discovery, the team of researcher Bertrand Routy, a professor in Université de Montréal’s Department of Medicine, shows one compound from the fruit can have a positive role to play in immunotherapy.

“With this research, conducted with our colleagues from Université Laval and McGill University, we have proved that castalagin, a polyphenol acting as a prebiotic, modifies the gut microbiome and improves immunotherapy response, even for cancers resistant to this type of treatment,” said Dr. Routy.

“Our results pave the way for clinical trials that will use castalagin as a complement to medications called immune checkpoint inhibitors in cancer patients,” added Meriem Messaoudene, a postdoctoral student in Dr. Routy’s lab and first author of the study.

In recent years, immune checkpoint inhibitors (ICI) have given patients renewed hope that their immune systems can overcome cancer resistance by revolutionizing therapies targeting melanoma and lung cancer. This type of immunotherapy activates the immune system to kill cancer cells.

A hunt for new approaches

Despite these improvements, only a minority of patients have long-lasting responses to immunotherapy akin to a cure, so researchers like Routy have been on the hunt for new therapeutic approaches. Their ultimate goal is to turn an unhealthy microbiome into a healthy one in order to strengthen the immune system.

Among the strategies Routy has come up with is one that employs prebiotics, chemical compounds that can improve the composition of the gut microbiome.

“To evaluate the beneficial effects of castalagin, we orally administered the prebiotic to mice that had received a fecal transplant from patients resistant to ICI,” he said. “We found that castalagin binds to a beneficial intestinal bacteria, Ruminococcus bromii, and promotes an anti-cancer response.”

The discovery will soon be tested in patients thanks to the launch of the first clinical trial combining the camu-camu berry and ICIs. Recruitment of 45 patients with lung cancer or melanoma will begin this month at the CHUM and the Jewish General Hospital.

Story Source:

Materials provided by University of Montreal Hospital Research Centre (CRCHUM). Note: Content may be edited for style and length.

[ad_2]

Source link

Find us on

Latest articles

- Advertisement - spot_imgspot_img

Related articles

Important 5 Things to Know before Starting Crossfit Training

Exercise is good for health. We all know about it and brands and the health industry agree...

Jason “The Athlete” MacDonald Approved CrossFit for MMA a...

Cross fit is a great exercise that helps in strengthening the body but also helps in building...

Here’s How and Why Boxing Conditioning Can Benefit CrossFit...

When you get into the ring, you never want to give up. It is all about how...

CrossFit World Champion Turned BJJ Blue Belt Explains Benefits...

The world of BJJ is a fascinating yet scary place. People are fascinated about the overall progress...

Lymphatic disorder may cause stillbirth or severe, chronic disease...

In a world first discovery, South Australian researchers have identified a genetic mutation responsible for a...

New fluorescent DNA label reveals nanoscopic cancer features —...

Researchers have developed a new fluorescent label that gives a clearer picture of how DNA architecture...